Evaluation of Bacteriophage Therapy Against Multidrug-Resistant Pseudomonas aeruginosa Isolated from Wound Infections at Ahmadu Bello University Teaching Hospital, Zaria

Authors

  • Shuaibu Mani Department of Microbiology, Faculty of Life Sciences, Federal University Dutsin-Ma, Katsina State, Nigeria https://orcid.org/0009-0006-8557-0214
  • Ignatius Mzungu Department of Microbiology, Faculty of Life Sciences, Federal University Dutsin-Ma, Katsina State, Nigeria
  • Adetunji M. Kilani Department of Microbiology, Faculty of Life Sciences, Federal University Dutsin-Ma, Katsina State, Nigeria
  • Ameh. E Rosemary Ahamadu Bello university, Zaria

DOI:

https://doi.org/10.33003/sajols-2025-0303-05

Abstract

The global rise of multidrug-resistant (MDR) bacteria has reignited interest in alternative therapeutic options such as bacteriophage therapy. This study evaluates the effectiveness of bacteriophages isolated from hospital sewage in combating MDR Pseudomonas aeruginosa strains obtained from wound infections in Ahmadu Bello University Teaching Hospital, Zaria. Fifteen clinical isolates were reconfirmed using conventional biochemical tests, followed by antibiotic susceptibility testing. Eight isolates were identified as MDR. Bacteriophages were isolated using standard enrichment and double-layer agar methods and displayed visible lytic activity against the resistant strains. The findings highlight the potential of bacteriophages as an effective and economical therapeutic alternative.

Downloads

Published

2025-09-30

How to Cite

Mani, S., Mzungu, I., Kilani, A. . M., & Rosemary, A. E. (2025). Evaluation of Bacteriophage Therapy Against Multidrug-Resistant Pseudomonas aeruginosa Isolated from Wound Infections at Ahmadu Bello University Teaching Hospital, Zaria. Sahel Journal of Life Sciences FUDMA, 3(3), 33–36. https://doi.org/10.33003/sajols-2025-0303-05

Issue

Vol. 3 No. 3 (2025): Sahel Journal of Life Sciences FUDMA (SAJOLS)

Section

Research Articles