Antioxidant and Antibacterial potential of Methanol root Extract of Kigelia africana (Sausage tree)

Abstract

Kigelia africana popularly known as the cucumber or sausage tree that possesses medicinal and traditional uses like anticancer, antiulcer, anti-aging, antioxidant, and anti-malarial activity.This study aimed to investigate GCMS, FTIR, Antioxidant and Antibacterial properties of methanolic root extract of Kigeliaafricana.The antioxidant activity of root extracts of Kigelia was evaluated by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical assay, Reducing power (PR) assay, Ferric Reducing Power assay and Nitric oxide (NO) radical scavenging assay. Ascorbic acid was used as a standard antioxidant. GCMS analysis reveals the presence of 9-Octadecanoic acid (z)-methyl ester while theFTIR spectral analysis identify some functional group such as hydroxyl group, Carboxyl group, methyl group, carbonyl group, amino group, and phosphate group.         In vitro antibacterialactivityof the extracts wastestedagainst4bacterialstrains viz; Staphylococccus aureus, Escherichia coli, Pseudomonas aeruginosa, and Salmonella spp.The highest antibacterial activity was found against Staphylococcus aureus then followed by Pseudomonas aeruginosa, Salmonella spp and Escherichia coli. The extract showed much higher scavenging activity against DPPH and with most reducing power against ferric cyanide. This study reveals the potency of the root of K. africana to be used as a good natural source for antioxidant and antibacterial activity.